The adidas Energy Boost 2.0 is probably the most comfortable shoe I've ever worn. They will run you $160+ but you get what you pay for. Also, consider you're either in bed or in a pair of shoes 90% of your life, so it's not a bad idea to invest in a good pair of running shoes.
These came highly recommended to me by a friend but I normally don't like adidas all that much. First, they are what the Nike Lunarglide wants to be. A much higher quality shoe that is light as hell and features an amazing upper construction. One of the lightest shoes you will find.
Then, there's the sole. This thing is like walking on a cloud. It has a high "drop" (meaning the heel is higher up that the toe area) which may pose problems for some serious runners. I've had no problems so far though. If you're going to be on your feet for hours at a time, this is also a wonderful and functional shoe.
The bottom line: These are at least worth trying on the next time you go to a shoe store. It's unlike anything else on the market and is the first "futuristic" shoe I've ever actually believed the hype on. The Boost material is for real and adidas knocked it out of the park with this model. It's also a very sleek looking shoe that is narrow and not bulky. Highly recommended ru